The Lab Principal Investigator

Michael J. Pecaut, Ph.D.

Students

None

Research Tech

Erben Bayeta, M.S.

Collaborating Investigators LLU

Daila S. Gridley, Ph.D.

Denise L. Bellinger, Ph.D.

Xian Luo-Owen, Ph.D.

Paul Haerich, Ph.D.

Richard E. Hartman, Ph.D.

Lora M. Green, Ph.D.

Gregory A. Nelson, Ph.D.

Vivian Mao, M.S.

Cecile Favre, Ph.D.

Clemson

Ted A. Bateman, Ph.D.

Colorado

Virginia L. Ferguson, Ph.D.

Louis S. Stodieck, Ph.D.

KSU

Stephen Keith Chapes, Ph.D.

VCU

Michelle L. Block, Ph.D.

Collaborating Labs

LLUMC Proton Treatment Center

BioServe Space Technologies

Bateman Osteoporosis Biomechanics Laboratory

Former Students

Cara Zuccarelli Eggers, Ph.D.

Farnaz P. Baqai, Ph.D.

Kristi Haynes, C.T. (A.S.C.P.)

Cory Pan

Peer Reviewed Published Articles

Tian J, Pecaut MJ, Coutrakon GB, Slater JM, Gridley DS. Response of extracellular matrix regulators in mouse lung after exposure to photons, protons and simulated solar particle event protons. Radiat Res. 2009 Jul;172(1):30-41.

PubMed: Abstract

Baqai FP, Gridley DS, Slater JM, Luo-Owen X, Stodieck LS, Ferguson VL, Chapes SK, & Pecaut MJ, Effects of spaceflight on innate immune function and antioxidant gene expression. J Appl Physiol 106(6):1935-42, 2009.

PubMed: Abstract

Gridley DS, Rizvi A, Luo-Owen X, Makinde AY, Pecaut MJ. Low dose, low dose rate photon radiation modifies leukocyte distribution and gene expression in CD4(+) T Cells. J Radiat Res (Tokyo). 2009 Mar;50(2):139-50.

PubMed: Abstract

Gridley DS, Pecaut MJ, Rizvi A, Coutrakon GB, Luo-Owen X, Makinde AY, & Slater JM, Low-dose, low-dose-rate proton radiation modulates CD4(+) T cell gene expression. Int J Radiat Biol. p. 1-12, 2009.

PubMed: Abstract

Ortega, MT, Pecaut MJ, Gridley DS, Stodieck LS, Ferguson V & Chapes SK. Shifts in bone marrow cell phenotypes caused by spaceflight. J Appl Physiol. 106(2): 548-55, 2009.

PubMed: Abstract

Gridley, DS, Slater JM, Luo-Owen X, Rizvi A, Chapes SK, Stodieck LS, Ferguson VL & Pecaut MJ. Spaceflight effects on T lymphocyte distribution, function and gene expression. J Appl Physiol. 106(1): 194-202, 2009.

PubMed: Abstract

Lloyd SA, Bandstra ER, Travis ND, Nelson GA, Bourland JD, Pecaut MJ, Gridley DS, Willey JS, Bateman TA. Spaceflight-relevant types of ionizing radiation and cortical bone: Potential LET effect? Adv Space Res. 42(12):1889-1897, 2008.

PubMed: Abstract

Willey, JS, Grilly LG, Howard SH, Pecaut MJ, Obenaus A, Gridley DS, Nelson GA & Bateman TA. Bone architectural and structural properties after 56Fe26+ radiation-induced changes in body mass. Radiat Res. 170(2): 201-7, 2008.

PubMed: Abstract

Pecaut, MJ & Gridley DS. Radiation and secondary immune response to lipopolysaccharide. In Vivo. 22(4): 423-34, 2008.

PubMed: Abstract

Gridley, DS, Obenaus A, Bateman TA & Pecaut MJ. Long-term changes in rat hematopoietic and other physiological systems after high-energy iron ion irradiation. Int J Radiat Biol. 84(7): 549-59, 2008.

PubMed: Abstract

Bandstra ER, Pecaut MJ, Anderson ER, Willey JS, De Carlo F, Stock SR, Gridley DS, Nelson GA, Levine HG & Bateman TA. Long-Term Dose Response of Trabecular Bone in Mice to Proton Radiation. Radiat Res. 169, 607-614, 2008.

PubMed: Abstract

Gridley DS, Rizvi A, Luo-Owen X, Makinde AY, Coutrakon GB, Koss P, Slater JM & Pecaut MJ. Variable hematopoietic responses to acute photons, protons and simulated solar particle event protons. In Vivo. 22(2):159-69, 2008.

PubMed: Abstract

Gridley DS, Coutrakon GB, Rizvi A, Bayeta EJ, Luo-Owen X, Makinde AY, Baqai F, Koss P, Slater JM & Pecaut MJ. Low-dose photons modify liver response to simulated solar particle event protons. Radiat Res. 169(3):280-7, 2008.

PubMed: Abstract

Gridley DS, Miller GM & Pecaut MJ. Radiation and Primary Response to Lipopolysaccharide: Bone Marrow-derived Cells and Susceptible Organs. In Vivo, 21(3):453-462, 2007.

PubMed: Abstract

Pecaut MJ, Dutta-Roy R, Miller GM & Gridley DS. Radiation and Primary Immune Response to Lipopolysaccharide: Lymphocyte Distribution and Function. In Vivo, 21(3):463-470, 2007.

PubMed: Abstract

Gridley DS & Pecaut MJ. Whole-body irradiation and long-term modification of bone marrow-derived cell populations by low- and high-LET radiation. In Vivo. 20(6B):781-9. 2006

PubMed: Abstract

Hamilton SA, Pecaut MJ, Gridley DS, Travis ND, Graham S, Newman IM, and Bateman TA. A Murine Model For Space and Therapeutic Radiation-Induced Bone Loss. J Appl Physiol. 101(3):789-93, 2006.

PubMed: Abstract

Pecaut MJ, Dutta-roy R, Smith AL, Jones TA, Nelson GA & Gridley DS, Acute effects of iron radiation on immunity, part I: population distributions. Radiat Res, 165(1): 68-77, 2006.

PubMed: Abstract

Gridley D, Dutta-Roy R, Andres M, Nelson G & Pecaut MJ, Acute effects of iron radiation on immunity, part II: leukocyte activation, cytokines, and adhesion. Radiat Res, 165(1): 78-87, 2006.

PubMed: Abstract

Haerich P, Nelson GA & Pecaut MJ, HZE Radiation and Dopaminergic Modification of Startle and Prepulse Inhibition in Mice. Physiol Behav, 86(1-2):103-10, 2005.

PubMed: Abstract

Pecaut MJ, Haerich P, Zuccarelli CN, Smith AL, Zendejas ED & Nelson GA. The effects of low-dose, high-LET radiation exposure on three models of behavior in C57BL/6 mice. Radiat Res, 162:148-156, 2004.

PubMed: Abstract

Pecaut MJ, Gridley DS & Nelson GA. Hypergravity-induced immunomodulation in a rodent model: Hematological and lymphocyte function analysis, J Appl Physiol, 97(1):29-38, 2004.

PubMed: Abstract

Pecaut MJ, Gridley DS, Moyers MF, Rabin B & Nelson GN. "Out-of-Field" effects of head-localized proton irradiation on immunity, In Vivo. 17(6):513-521, 2003.

PubMed: Abstract

Pecaut MJ, Nelson GA, Peters LL, Kostenuik PJ, Bateman TA, Morony S, Stodieck LS, Lacey DL, Simske SJ & Gridley DS. Effects of spaceflight on immunity in the C57BL/6 mouse, Part I: Immune population distributions. J Appl Physiol. 94:2085-2094, 2003.

PubMed: Abstract

Gridley DS, Nelson GA, Peters LL, Kostenuik PJ, Bateman TA, Morony S, Stodieck LS, Lacey DL, Simske SJ & Pecaut MJ. Effects of spaceflight on immunity in the C57BL/6 mouse, Part II: Activation, cytokines, erythrocytes, and platelets. J Appl Physiol. 94:2096-2103, 2003.

PubMed: Abstract

Pecaut MJ, Gridley DS & Nelson GA. Long term effects of low dose whole-body proton irradiation on immunity: Shielded vs unshielded. Aviat Space Environ Med. 74(2):115-24, 2003.

PubMed: Abstract

Pecaut MJ, Haerich P, Zuccarelli CN, Smith AL, Zendejas ED, Nelson GA. Behavioral consequences of radiation exposure to simulated space radiation in the C57BL/6 mouse: Open-field, Rotorod, and Acoustic Startle. Cogn Affect Behav Neurosci. 2(4):329-40, 2002.

PubMed: Abstract

Gridley DS, Pecaut MJ, Green LM, Miller GM & Nelson GA. Hypergravity-induced modulation of lymphocyte responses using an intact mammalian model. J. Gravitational Physiol. 9(2):15-27, 2002.

PubMed: Abstract

Gridley DS, Pecaut MJ & Nelson GA. Total-body irradiation with high-LET particles: Acute and chronic effects on the immune system. Am J Physiol - Regul Integr Comp Physiol. 282:R677-688, 2002.

PubMed: Abstract

Gridley DS, Pecaut MJ, Dutta-Roy R & Nelson GA. Dose and dose-rate effects of whole-body proton irradiation on leukocyte populations and lymphoid organs: Part I. Immunol Letters. 80:55-60, 2002.

PubMed: Abstract

Pecaut MJ, Gridley DS, Smith AL & Nelson GA. Dose and dose rate effects of whole-body proton-irradiation on lymphocyte blastogenesis and hematological variables: Part II. Immunol Letters 80:67-73, 2002.

PubMed: Abstract

Pecaut MJ, Nelson GA & Gridley DS. Dose and dose-rate effects of whole-body gamma-irradiation: I. Lymphocytes and lymphoid organs. In Vivo 15:195-208, 2001.

PubMed: Abstract

Gridley DS, Pecaut MJ, Miller GM, Moyers MF & Nelson GA. Dose and dose-rate effects of whole-body gamma-irradiation: II. Hematological variables and cytokines. In Vivo 15-209-216, 2001.

PubMed: Abstract

Pecaut MJ, Smith AL, Jones TA & Gridley DS. Modification of immunological variables by method of CO2 euthanasia. Comparative Med 50:595-602, 2000.

PubMed: Abstract

Pecaut MJ, Simske SJ & Fleshner M. Spaceflight induces changes in splenocyte subpopulations: effectiveness of ground-based models. Am J Physiol: Regulatory Integrative Comparative Physiology 279:R2072-R2078, 2000.

PubMed: Abstract

Todd P, Pecaut MJ & Fleshner M. Combined effects of space flight factors and radiation on humans. Mutation Res. 430:211-219, 1999.

PubMed: Abstract

Campbell JA, Pecaut MJ & Luttges M. Prevalence and arrangement of lignified vascular elements in 6-day-old alfalfa (Medicago sativa L.) seedlings raised in reduced gravity. J Plant Physiol, 149:539-547, 1996.

Book Chapter

Gridley, D.S., Green, L.M., Nelson, G.A., Pecaut, M.J., and Slater, J.M. Cancer, radiotherapy and SOD mimetics. In: Therapeutic Applications of Superoxide Dismutase and Its Mimetics (D. Salvemini and S. Cuzzocrea, Eds.), Georgetown: Landes and New York: Springer, 2006 (epub ahead of print www.eurekah.com)